Descriptif
Over the last two decades, several techniques were developed to probe the mechanical properties of biological matter at the nanometer to the micrometer level. These techniques revealed the important role played by mechanical aspects in the regulation of cellular physiological and pathological processes. It is thus now clear that physical parameters come into play the regulation and the development of diseases such as atherosclerosis and cancer. While it is not possible to predict which will be the future techniques that will overpass the limits of the current ones, it is to be bet that many will have as a base - at least partly - the principles of measures currently involved.Objectifs pédagogiques
Pedagogical objectives A prime objective of this course is thus to provide the tools to understand what mechanical property can be measure nowadays with modern techniques. The principle of these techniques will be covered (deflection of a cantilever, photonic or magnetic force, stretching of a substrate, fluid stress in a microfluidic chip, etc) and the models used to analyse data obtained using them, including basic contact mechanics and rheological models for the cellular scales (1-10µm), or force spectroscopy for the molecular scales (1-10 nm). The range of operation, resolution and limits of these techniques will be approached through concrete examples in catch with current research in biomechanics, biophysics, or bioengineering. The course will have several secondary objectives, such as describing research and innovation at the interface between mechanics and biology, or tackling variability in measurements on biological samples
32 heures en présentiel
